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Although these experiments had no effects on tumor viability, the concept was later picked up by Wilhelm Brünings 178 , 179 who combined maximally tolerable doses of insulin treatment with a KD into a ‘de-glycation method’ (‘Entzuckerungsmethode’) for the treatment of head and neck cancer patients in his clinic

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Thus, Hyp potently and concentration-dependently inhibited the enzymatic conversion of PGH 2 to PGE 2 catalyzed by mPGES-1 in a defined cell-free assay, diminished the formation of PGE 2 in human whole blood without affecting the synthesis of other COX-derived prostanoids (i.e., 6-keto PGF 1α , TXB 2 , and 12-HHT), and reduced PGE 2 levels in the pleurisy model in vivo