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Early Alzheimer's disease pathology in human cortex involves transient cell states: Cell

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High immunization coverage and early and correct management of cases of infectious disease play major roles in the prevention and treatment of protein–energy malnutrition.13 In poor communities, the treatment of helminth infections 3 times per year improved child growth and development.15 Protein–energy malnutrition and diarrhea typically interact in a vicious cycle, but the control of diarrhea depends on more than medical help.30 , 67 Although growth monitoring is considered potentially important in child health clinics, there is often a lack of appropriate follow-up action.6 , 68 , 69 , 70 As much as functional health services may need to be made available, in order to address infectious diseases as a cause of protein– energy malnutrition it is likewise important to promote breast-feeding, improve the water supply and sanitation, and educate people about hygiene.7 , 15 , 71 , 72 , 73 , 74 The multifaceted horizontal approach of the WHO-supported Integrated Management of Childhood Illness initiative has recently been shown to be an effective strategy.75 , 76 Micronutrient deficiencies Epidemiology Deficiencies in iron, iodine, vitamin A and zinc are still major public health problems in developing countries, but vitamin C, D and B deficiencies have declined considerably in recent decades.7 , 77 Micronutrient deficiencies affect at least 2 billion people worldwide.5 As there are often no reliable biochemical indices of marginal micronutrient status, randomized controlled trials of supplementation are the best method to study the relation between micronutrient deficiencies and health parameters in human populations.78 Globally, 740 million people are deficient in iodine, including up to 300 million with goitre and 20 million with brain damage from maternal iodine deficiency during their fetal development.7 , 79 , 80 , 81 About 2 billion people are deficient in zinc