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Most clinical studies progress through four distinct phases—Phase I, Phase II, Phase III, and Phase IV—each playing a critical role in assessing dosage, effectiveness, side effects, and long-term outcomes
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Since normal epithelial barrier function is determined in part by the integrity of the AJC, it was initially hypothesized that defects in this structure, made of tight junctions and adherens junctions, led to alterations in intestinal permeability seen in cases of IBD
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