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Variability in mucociliary clearance speed and mucus thickness, often affected by patient conditions such as anatomical differences, inflammation or allergies, and even the technique of administration (angle of spray, depth of insertion) (Riese et al., 2014), can alter drug absorption and uptake into the brain

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Patients often notice a gentle glow after the first session, while deeper concerns such as melasma, sun spots, tanning, and long-standing dark patches fade gradually with repeated treatments