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Upon polarizing to the M2 phenotype at the injury site, macrophages secrete anti-inflammatory cytokines (IL-10, TGF-β), angiogenic growth factors (VEGF, bFGF, PDGF), and matrix metalloproteinases (MMP-2, MMP-9, MMP-13), thereby reducing inflammation, promoting angiogenesis, and remodeling the extracellular matrix, playing an active role in wound repair 6,48
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